We investigated the effect of glutathione supplementation on body weight gain, feed intake, velvet antleryield and economic analysis in elk bulls. A total 14, 2-year old male elks were divided into 2 groups withcontrol or glutathione treatment. Elks were fed concentrate feed at the level of 1.5% relative to body weight (3.1kg). and allowed to consumed hay as roughage ad libitum. Glutathione was supplemented at the level of 6mg/kg. Average daily gains (ADG) for 2-years old elks were 234.1±7 and 247.6±22 kg in control andglutathione fed groups, respectively. Treated group had higher ADG than control (p<0.05). Individual daily DMintakes were 5.34±0.70 and 5.64±0.71 kg in control and glutathione supplemented groups, respectively.Glutathione-fed group showed an additional intake of 298 g on an average. Production of velvet antlers for elkyearlings was 4,229±720 g and 4,653±960 g in control and glutathione supplemented groups respectively.Analysis of economics efficiency revealed 8% higher revenue index in glutathione supplemented groups. Inconclusion, glutathione supplementation showed increase of DM intake and ADG in elk bulls, and could alsoincrease velvet antler production.