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ISSN : 1225-2964(Print)
ISSN : 2287-3317(Online)
Annals of Animal Resource Sciences Vol.22 No.2 pp.77-83

한우에서 Myopalladin (MYPN) 유전자의 A1795G SNP의 다형성 및 도체형질 관련성 분석

홍민욱1, 김 훈1, 박새롬1, 이승규1, 이영섭1, 김진우1, 김기범2, 이선영3, 송영한1, 이성진1*
강원대학교 동물생명과학대학1, 축산물품질평가원2, 한국마사회3

Association Analysis between A1795G Single Nucleotide Polymorphism (SNP) in Myopalladin (MYPN) Gene and Carcass Traits in Korean Cattle

Sung-Jin Lee1*, Min-wook Hong1, Hun Kim1, Sairom Park1, Seung-kyu Lee1, Yeung-sub Lee1, Jin-woo Kim1, Ki-Beom Kim2, Sun-Young Lee3, Young-Han Song1
1College of Animal Life Sciences, Kangwon National University
2Korea Institute for Animal Products Quality Evaluation
3Racing Laboratory, Korea Racing Authority


Myopalladin (MYPN) is an important expression gene associated with regulation of Z-line structure in muscleand maintains sarcomeric integrity. In this study, we investigated the association between MYPN A1795G SNP(single nucleotide polymorphism) and carcass traits (LMA, longissimus muscle area; CW, carcass weight; BF,backfat thickness; MS, marbling score) in Korean cattle. The MYPN A1795G SNP was genotyped in 212 steersand analyzed the associations with carcass traits by PCR-RFLP (Restriction fragment length polymorphism)method. The allele frequencies were 0.566 for G allele and 0.434 for A allele. And the genotype frequencies ofGG, GA, and AA genotype were 32.1%, 49%, and 18.9%, respectively. Association analysis indicated that theA1795G SNP of MYPN gene showed a significant association with LMA (p<0.05). The steers with GG genotypehad higher LMA than those with the genotypes AA. But no significant associations were observed in othercarcass traits (CW, BF, MS). The steers with the GG genotype showed higher CW and BF than those with thegenotypes AA and GA. These results suggest that the A1795G SNP of the MYPN gene is associated with LMAand may be useful for candidate marker-assisted selection to increase the levels of LMA in Korean cattle.