ISSN : 1225-2964(Print)
ISSN : 2287-3317(Online)
ISSN : 2287-3317(Online)
한우에서 Myopalladin (MYPN) 유전자의 A1795G SNP의 다형성 및 도체형질 관련성 분석
Association Analysis between A1795G Single Nucleotide Polymorphism (SNP) in Myopalladin (MYPN) Gene and Carcass Traits in Korean Cattle
Abstract
Myopalladin (MYPN) is an important expression gene associated with regulation of Z-line structure in muscleand maintains sarcomeric integrity. In this study, we investigated the association between MYPN A1795G SNP(single nucleotide polymorphism) and carcass traits (LMA, longissimus muscle area; CW, carcass weight; BF,backfat thickness; MS, marbling score) in Korean cattle. The MYPN A1795G SNP was genotyped in 212 steersand analyzed the associations with carcass traits by PCR-RFLP (Restriction fragment length polymorphism)method. The allele frequencies were 0.566 for G allele and 0.434 for A allele. And the genotype frequencies ofGG, GA, and AA genotype were 32.1%, 49%, and 18.9%, respectively. Association analysis indicated that theA1795G SNP of MYPN gene showed a significant association with LMA (p<0.05). The steers with GG genotypehad higher LMA than those with the genotypes AA. But no significant associations were observed in othercarcass traits (CW, BF, MS). The steers with the GG genotype showed higher CW and BF than those with thegenotypes AA and GA. These results suggest that the A1795G SNP of the MYPN gene is associated with LMAand may be useful for candidate marker-assisted selection to increase the levels of LMA in Korean cattle.
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