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ISSN : 1225-2964(Print)
ISSN : 2287-3317(Online)
Annals of Animal Resource Sciences Vol.25 No.1 pp.49-55

한우 배최장근 조직 내 Insulin-like Growth Factor-1(IGF-1) 유전자의 발현 근내지방도와의 연관성 분석

윤효정1,2, 성지연1, 오재돈1, 유소연2, 황승용2, 공홍식1*
한경대학교 유전정보연구소1, 지노첵2

Association of Insulin-like Growth Factor-1 (IGF-1) Gene Expression with Marbling Score in M. Longissimus Tissue of Korean Cattle (Hanwoo)

Hong Sik Kong1*, Hyojeong Yoon1,2, Jiyeon Seong1, Jae Don Oh1, Soyoen Yoo2, Seungyong Hwang2
1Genomic Informatics Center, Hankyong National University
(Received 14 April 2014, Revised 17 June 2014, Accepted 18 June 2014)


Recently, with the increase of meat production, high quality and safety of meat have been stronglyemphasized by Korean consumers. Marbling in beef has been regarded as an important criterion decidingmeat quality in Korea. The purpose of this study was to identify the transcriptional level of insulin-like growthfactor-1 (IGF-1) in longissimus muscle samples of 46 Hanwoo. The level of IGF-1 transcripts was measured byreal-time polymerase chain reaction (PCR) and molecular connection of IGF-1 was analyzed using thePathway Studio program (Ver 9.0). Increase of marbling score (MS) induced increase of IGF-1 transcripts levelin the muscle and there is a significant correlation (p<0.05) between IGF-1 mRNA expression and MS. Thepathway study showed that IGF-1 genes are regulated in insulin, fatty acid synthase, leptin, andcorticotrophin releasing hormone. These results suggest that IGF-1 might be used as a useful marker for theimprovement of economic traits in Hanwoo.