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ISSN : 1225-2964(Print)
ISSN : 2287-3317(Online)
Annals of Animal Resource Sciences Vol.26 No.1 pp.6-12

Effects of C1032T SNP in IGFBP2 Gene on Growth and Egg Production Traits in Chickens

So-Young Choi1, Jong-Young Won1, Chong-Dae Kim2, Yeong Ho Hong3, Dong-Kee Jeong4 and Sung-Jin Lee1*
1College of Animal life Sciences, Kangwon National University, Korea
2Poultry Science Division, National Institute of Animal Science, R.D.A., Korea,
3Department of Animal Science and Technology, Chung-Ang University, Korea,
4Department of Animal Biotechnology, Cheju National University, Korea
*Corresponding author: Sung-Jin Lee, Dept. of Animal Biotechnology, College of Animal Life Sciences, Kangwon National University,
Chuncheon 200-701, Korea. Tel: +82-33-250-8636, E-mail:


The insulin-like growth factor binding proteins (IGFBPs) is involved in the regulating effects and the
biological activities of the insulin-like growth factors (IGFs). Recently, It has been reported that the IGFBP2
gene polymorphism was associated growth and skeletal development in chicken. This study was designed to investigate the association of the C1032T SNP of IGFBP2 gene with growth and egg production traits in Korean native chicken (KNC) population as well as other chicken breeds. A total of 225 chickens from the three breeds (Rhode Island Red, Cornish, Leghorn) and 245 chickens from the six strains of Korean native chickens including Black, Gray, Ogol, Red, White, and Yellow, were genotyped by PCR-RFLP (polymerase chain reaction-restricted fragment length polymorphism) and analyzed the association between their genotypes and economic traits by SAS program. The results showed that the SNP (single nucleotide polymorphism) was significantly associated with multiple traits, including body weight of 150 days (p<0.001 and p<0.05) in the Rhode Island Red and the KNC (White) and egg production number (p<0.05) in the KNC (Black) breed. These results suggest that IGFBP2 C1032T SNP could be used as a DNA marker for the improvement of economic traits in Korean native chicken breeding.

IGFBP2 유전자 C1032T SNP가 닭의 산란 및 육량 형질에 미치는 영향

1강원대학교 동물생명과학대학
2농촌진흥청 국립축산과학원
3중앙대학교 동물생명공학과
4제주대학교 생명과학부