This study was conducted to investigate the effects of a physico-chemical treatment on the reduction of odorous compounds from a swine farm. The physico-chemical treatment consisted of a system with a curtain and a spray of ozonated water. This treatment is a physical one for collecting the exhausted air, odor gas inside the curtain and additionally a chemical treatment because it comprises an ozonated water spray to remove odor compounds by ozone oxidation. Ammonia, hydrogen sulfide, trimethylamine, volatile organic compound, and complex odor were found in high concentrations in the pigsty before and after installation of the physico-chemical treatment system, but the concentration of odorous compounds outside the curtain and on the perimeter of the swine farm decreased significantly (p<0.01). The volume of odorous compounds also showed a similar trend as that for the odorous compound concentration. The results of this study showed that the concentration of all odorous compounds inside the pigsty were high regardless of the season, with spring and winter accounting for the highest values due to minimum ventilation. Outside the curtain and perimeter of the site, the concentration of odorous compounds and odor generation fluctuated according to the ventilation intensity of the pigsty. Almost no odorous compounds were detected in spring and winter when ventilation intensity is low, and high concentrations of odorous compounds were found in summer and autumn (p<0.01). The conclusions of this study are that the concentrations of odorous compounds emitted from pigsties can be reduced by more than 90% by filtering, disassembling and sterilizing the curtain and ozonated water spray system. Therefore, it is expected that this system will alleviate the problems caused by the diffusion of odorous compounds and improve the acceptance levels of intensive pig farming.