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ISSN : 1225-2964(Print)
ISSN : 2287-3317(Online)
Annals of Animal Resource Sciences Vol.30 No.3 pp.97-104

Genome-wide Association Study Analysis for Explore of Candidate Genes Affecting Weight of 10 Week Old Traits in Purebred Landrace

Ho-Chan Kang1,Jae-Bong Lee2,Chae-Kung Yoo3,Tae-Jeong Choi4,Hyun-Tae Lim1,3*
1Department of animal science, Gyeongsang National University, Jinju 52828, Korea
2Korea Zoonosis Research Institute (KoZRI), Chonbuk National University, Iksan 54531, Korea
3Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea
4Swine Science Division, National Institute of Animal Science, RDA, Cheonan 31000, Korea
* Corresponding author: Hyun-Tae Lim, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea. Tel: +82-55-772-1945


According to Livestock Inspection Standards, the piglets enter the feedlot at approximately 30 kg, and the inspection starts after the preliminary feeding period. The reason for applying the preliminary feeding period is to select inspection piglets with no diseases after the complete growth of the internal organs until 10 weeks of age. Furthermore, the age of 10 week is the time when the muscle fibers grow to their maximum size and the piglets are prepared for fat deposition at the later fattening period. In the study, a genome-wide association study (GWAS) was performed through the mlma command of the genome-wide complex trait analysis (GCTA) program with 703 purebred Landrace population, and the candidate genes associated with the weight of 10 week were searched. The GWAS identified 3 single nucleotide polymorphism (SNP) markers, which have a significant genome-wide suggestive level, on chromosome 6 (DIAS0002615; p-value=1.62×10-6, MARC0083933; p-value=4.94×10-6, ASGA0028717; p-value=5.40×10-6). The 2 genes (Ubiquitin protein ligase E3 component n-recognin 4; UBR4, WD and tetratricopeptide repeats 1; WDTC1) in which these 3 SNP markers are located are positional candidate genes of the weight of 10 week of the purebred Landrace population. 2 candidate genes have been reported to be associated with fattening. Therefore, the positional candidate genes in this study, UBR4 and WDTC1, are expected to be usable as genes for traits associated with the weight of 10 week weight and fattening through additional experimental research with other population.

순종 랜드레이스의 10주령 체중 형질에 영향을 미치는 후보유전자 탐색을 위한 전장유전체 분석

경상대학교 농업생명과학대학 축산학과1, 전북대학교 인수공통전염병연구소2, 경상대학교 농업생명과학연구원3,농촌진흥청 국립축산과학원 양돈과4