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ISSN : 1225-2964(Print)
ISSN : 2287-3317(Online)
Annals of Animal Resource Sciences Vol.31 No.3 pp.82-86

Association between the g.7516G>C SNP in the Fatty Acid Binding Protein 4 Gene and Economic Traits in Hanwoo

Seung-Kyoo Lee1#,Young-Sub Lee1#\,Hun Kim1,Yun-Ho Bae1,Sung-Jin Lee2*
Graduate Students, 2Professor, College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Korea
# Both authors contributed equally to this manuscript
* Corresponding author: Sung-Jin Lee, Department of Animal Biotechnology, Kangwon National University, Chuncheon 24341, Korea. Tel: +82-33-250-8636, E-mail:


The fatty acid binding protein 4 (FABP4) gene plays an important role in lipid metabolism and homeostasis in adipocytes. The objective of this study was to analyze the association between a single nucleotide polymorphism (SNP), g.7516G>C, in the FABP4 gene and economic traits of Korean native cattle, Hanwoo. Primers were designed to target a region of the FABP4 gene between nucleotides 7417 and 7868 (AAFC01136716). The SNP, which was detected by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) method using restriction enzyme MspA1I, was genotyped in 319 animals of Hanwoo steer population. Statistical analysis showed that the SNP genotype of the FABP4 gene significantly affected carcass weight (CW, p<0.01), longissimus muscle area (LMA, p<0.001), and marbling score (MS, p<0.001). GG allele of the SNP on 246 animals in a Wagyu × Limousin F2 reference population showed a higher MS (p<0.05) and subcutaneous fat depth (p<0.05) in previous report. But CC allele of the SNP showed greater values for MS, LMA, and CW in Hanwoo steers. These results suggest that the g.7516G>C SNP located in the FABP4 gene may affected differently depending on the cattle breed and can be used as a genetic selection marker in Korean native cattle.

한우 Fatty Acid Binding Protein 4 유전자 g.7516G>C SNP와 경제형질과의 연관성 분석

강원대학교 동물생명과학대학 대학원생1, 교수2